That’s strongly hinted in Captain America #617:
Bucky: The Wolf Spider experiement. I hadn’t thought of it in decades. The male trials of the Black Widow procedure. It never produced an operative Department X’s Red Room was satisfied with.
I’m not sure I’d say it’s the entire point, because Ivan got the treatment too, and like I said, writers haven’t handled this plot point with much consistency. But it’s something that shades the existing stories in an interesting way; something I’d be interested in learning more about in future stories.
dictionary00 asked: I always thought that Natasha's serum was the same as Nick Fury's anti-aging serum - is this untrue?
It’s never been called the Infinity Formula either. It has pretty similar properties, though, except for the side effects.
It’s hinted that Natasha’s chemical turns people evil, explaining the erratic behavior of Ivan in Deadly Origins and the failure of the Ghost Spider program in the Gulag arc of Captain America. Also, Nick needed yearly doses of the Infinity Formula keep him from rapidly aging. (He’s had it his system for so long he doesn’t need it anymore— it’s a dangling plot point whether the dose that Bucky got after Fear Itself will run out on him.)
So yeah, at least imho they’re different things.
queerasasevendollarbill asked: I have some "friends" who absolutely refuse to believe me when I say that Natasha has been injected with a supersoldier serum and is a super soldier. I'm trying to get my hands on a copy of Black Widow Breakdown vol 1 no 2, because I know they talk about the red room super soldier program, but I figured maybe you might have scans of anything that talks about her being a super soldier or maybe even a post about it? you can pm me if that's easier for you
I do have a post about this— but, um, it’s mostly about how despite some mysterious enhancements, Natasha’s never been treated with the Super Soldier Serum. It’s a pretty widespread misconception, probably because Natasha’s abilities beyond “never aging” are not very well defined. (They tend to depend on who is writing the comic.)
Anyway. The Super Soldier Serum is a specific thing in the Marvel Universe, associated with Captain America. So “super soldier” doesn’t just mean trained combatant with biological enhancements, it means like, person with Captain America’s powerset. And so comics have been pretty careful to not call Natasha’s enhancements “super soldier” enhancements. Keeping her origins, her mythology, very much about her. The Red Room is really about individuality, and the idea that women can be manufactured, are replaceable. It’s not about making its operatives special, the way Steve Rogers is special; just the opposite.
Black Widow: Breakdown #2 does explore the Red Room “program” in the sense that it’s a story about Natasha and Yelena, their separate approaches to the same codename, but it doesn’t show what the Red Room was like, or deal with Natasha’s origins except thematically. You might mean Deadly Origin #2, which does deal with a “chemical” Natasha takes, to save her friend Ivan. There are scans from that issue in the post I linked.
Hopefully you and your friends find a way to get along in spite of the tortures of continuity!! I fear I haven’t helped much.
Some fun I had with Deodato’s Secret Avengers homage.
AVENGERS ASSEMBLE #25
KELLY SUE DECONNICK & WARREN ELLIS (W)
MATTEO BUFFAGNIX (A)
Cover by JORGE MOLINA
ALL-OUT WAR IN NEW YORK CITY!
• The demented Dr. June Covington has taken on A.I.M., and is winning. The Avengers are caught in the middle of this Mad Science War!
• But, now, this situation is more important — because there’s a second Terrigen cocoon in New York, ticking like a time bomb, about to go off, Covington wants it and A.I.M. has it.
• SPIDER-GIRL, who has been mentored by the Avengers in her search for her teacher, abducted by Covington for Nefarious Genetic Purposes, now leads the charge, as the Avengers Assemble to end this conflict before the Terrigen cocoon explodes and New York is doooooomed.